ABOUT CONOLIDINE ALKALOID FOR CHRONIC PAIN

Most recently, it's been determined that conolidine and the above derivatives act to the atypical chemokine receptor three (ACKR3. Expressed in comparable regions as classical opioid receptors, it binds to the big selection of endogenous opioids. Compared with most opioid receptors, this receptor acts for a scavenger and won't activate a 2nd messen

This compound was also tested for mu-opioid receptor activity, and like conolidine, was found to have no exercise at the website. Employing the same paw injection test, many alternate options with higher efficacy were being located that inhibited the Original discomfort reaction, indicating opiate-like activity. Specified the different mechanisms o